Simultaneous Determination of Ambroxol Hydrochloride, Cetirizine Hydrochloride, Methylparaben and Propylparaben in Liquid Pharmaceutical Formulation

Liquid preparations are particularly susceptible to microbial growth because of the nature of their ingredients. Such preparations are protected by the addition of preservatives that prevent the alteration and degradation of the product formulation [1]. The finished product release specifications should include an identification test and a content determination test with acceptance criteria and limits for each antimicrobial preservative present in the formulation [2]. The finished product self-life specification should also include an identification test and limits for the antimicrobial preservatives present [2]. Hence their (MP and PP) antimicrobial and antifungal properties make them an integral part of the product formulation. This encourages the development of new stability indicating method for simultaneous estimation of all compounds (AMB, CTZ, MP and PP) to provide driving force in today’s pharmaceutical industry.